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Are you interested in finding out how to get smoother, tighter, and wrinkle-free skin? The answer may be BOTOX® treatments

Read the following chapters to find out if BOTOX is right for you.


  1. What is BOTOX® and how does it function?

  2. How and why did BOTOX® attract so much attention in the world of cosmetic procedures?

  3. How do we get wrinkles?

  4. How can BOTOX® improve gummy smiles?

  5. BOTOX® does wonders with excessive sweating.

  6. How much BOTOX® is enough?

  7. Baby BOTOX® - smaller doses

  8. Can gents use BOTOX®?


BOTOX® is a derivative of the bacteria Clostridium botulinum. It was first discovered by Belgian scientist Emile van Ermengem after a botulism outbreak in Belgium. Today, it is a therapeutic agent also known as Botulinum Toxin Type A. This rod-shaped bacterium is widespread, can be found in the soil, and produces the neurotoxin botulinum. In the early 1900’s, Karl Friedrich Meyer developed techniques for growing and extracting the toxin. Today, BOTOX® is made in laboratories under controlled conditions and it is administered in extremely small doses.

To BOTOX® or not?

Toxin – you might ask yourself, how is BOTOX® safe then? YES! Yes to BOTOX®, and YES it’s safe! When placed strategically in small doses it can do wonders in the cosmetic and medical world.

Now that we know what BOTOX® is, let’s talk about its Mechanism of action, or how the product works.

Botulinum toxin is a neurotoxic protein that stops the release of the neurotransmitter called Acetylcholine. Acetylcholine is a molecule that works in the body as a messenger between the neuromuscular junctions of cells. It is released by motor neurons in the nervous system and activates muscle contraction.

Botulinum toxin works by releasing an enzyme that stops muscle contraction.


When you get BOTOX® injections they relax the muscles on your face that create wrinkles around the eyes and on the forehead. The wrinkles are reduced and your face looks smoother. Magic!

After BOTOX injections, muscle movements that create wrinkles are reduced. In general, BOTOX® lasts between 3 to 4 months. There are some patients in who it lasts longer, up to 6 months or shorter less than 3 months. How long BOTOX® lasts varies from patient to patient.

But now that we get the chemistry and pharmacological attributes, let’s dive into history of BOTOX®.


Today, the uses for BOTOX® are many. But before BOTOX® was even considered for cosmetic treatments it was used for completely different purposes - to treat crossed eyes and eye twitching. Scientists, that conducted this research, noticed that botulinum toxin reduced wrinkles in the glabellar (between the eyebrows and above the nose) part of the upper face. The first human patients who suffered from strabismus were injected with botulinum toxin type A in 1977, and soon after that hundreds of ophthalmologists were using it in the treatments.

In 1989, after thousands of patients received this treatment, Allergan received approval from the Food and Drug Administration to market Botulinum toxin type A to treat strabismus and blepharospasm (eye-twitching) under the trademark BOTOX®.

The potential for other usages of it was discovered quickly. Thus, it was in the early 1990’s that Botulinum toxin got its role in cosmetic procedures for wrinkle reduction. BOTOX® was on its way to becoming popular, and misunderstood.


Botulinum toxin was used for cosmetic purposes for the first time when a plastic surgeon treated forehead asymmetry. The asymmetry was caused by forehead nerve paralysis on the left side. More importantly, the treatment was successful and it made wrinkles on the right side smoother - it matched the left side that was paralyzed.

Other specialists from ophthalmology and dermatology fields noticed that patients who were treated from eye-twitches and received Botulinum Toxin type A around the eyes and upper face ended up with reduced glabellar lines (frown lines).

Overnight BOTOX® got became the aesthetic star of the show! In 2002, the FDA cleared BOTOX for temporarily reducing the appearance of moderate to severe glabellar lines.

The cosmetic use of BOTOX® has become widespread.

Below are the dates of various FDA approvals for botulinum toxin:

  • Crow's feet in 2013

  • Urinary incontinence in 2011

  • Chronic migraines in 2010

  • Axillary hyperhidrosis in 2004

  • Glabellar lines in 2002

  • Cervical dystonia in 2000

  • Strabismus and blepharospasm in 1989

Now that we covered history, let’s move on to the most popular usages of BOTOX®.


Wrinkles are a normal sign of aging; genetics may help determine how early you develop wrinkles, the depth and number of wrinkles, and where you get the wrinkles. However, lots of social and environmental factors play a part in the severity of wrinkles or rhytids. The big ones are UV exposure, smoking, a demanding work life balance, environmental pollutants, lack of good skin care, a diet deficient in fruits and vegetables, and repeated facial movements. Luckily, BOTOX® can really do wonders when it comes to wrinkle reduction around the mouth and eyes. BOTOX® can even help reduce some of the sagging that occurs in some areas of the face from repetitive movements.

Before we reveal the secrets of BOTOX® let’s talk about wrinkles in more detail.


Wrinkles are essentially dermal scars in the form of lines, furrows, and creases in your skin. This long term dermal trauma is a result of aging, is worsened by collagen and volume loss but is completely natural. Also, your skin loses elastin over time, and its ability to rejuvenate itself decreases. Your skin also gets pulled down by gravity.

How many and how severe your wrinkles will appear, depend tremendously on your lifestyle. A stressful, busy life can greatly contribute to these signs of aging.


Throughout our lifetime, we may develop three types of wrinkles: dynamic, static, and folds. Dynamic wrinkles are the ones that appear when your facial muscles move - when you laugh smile or squint. They are caused by contraction of muscles that are attached to the overlying skin. Each muscle contraction causes the skin to bunch together and form the lines between the bulk of the muscles. When the skin is still young, it can bounce back to being smooth, after the facial expression is over. That’s because it’s full of collagen, elastin, and other important proteins that keep it flexible and youthful. BOTOX® is an awesome solution for dynamic lines because it works as a prevention measure - it keeps dynamic lines from actually becoming wrinkles and staying on your face.

Some of the dynamic wrinkles include

  • Forehead wrinkles

  • Frown lines (between your eyebrows)

  • Crow’s feet (at the outer corner of your eyes)

  • Smile lines

  • Lip lines

Then as time passes and the skin gets older, dynamic wrinkles turn into STATIC WRINKLES….They are the bad ones, and they have a bad reputation for good reason. Once they appear on the face, they are there to stay. Their visibility is strong, and even though they start as small lines, they get deeper and deeper. The major cause of static wrinkles is the natural loss of collagen and elasticity. As the skin begins to age, collagen starts to break down and this results in folds, creases and lines. Static lines may also appear because of smoking, extended sun exposure or genetics.

Static wrinkles may Include:

  • Tear through lines (under the inner corners of the eyes)

  • Marionette lines (from the edge of the mouth down to the jawline)

  • Nasolabial lines (from your nose down to the outer corners of the mouth)

  • Lateral cheek lines

  • Necklines


BOTOX® is the most appropriate procedure for treating dynamic wrinkles because it reduces the muscle movements that cause them. BOTOX® injections relax the muscle contraction and dynamic wrinkles no longer occur.

Static lines are a bit trickier, but a proper dose of BOTOX® and repetitive treatments can soften them over time. Or the best solution would be a combination of BOTOX® and dermal fillers.


Do you want to find out how BOTOX® does wonders on the following facial wrinkles? Check out the list below.

1. Glabellar lines

More colloquially known as frown lines or ‘11’ lines, glabellar lines appear between your eyebrows and above your nose.

They are the first sign of aging for many people and they can first appear in the mid-20s. A lot of young people start with BOTOX® to stop the advancement of these wrinkles.

Glabellar lines become more noticeable as the skin loses collagen and elastin and are a natural part of aging. Muscles that contract between eyebrows in a downward movement make these lines stay permanent on the face. The result - people get a constant frowning look, and they appear older and angry all the time.

BOTOX® is a safe and absolutely effective non-surgical treatment for avoiding or reversing the frown face appearance. BOTOX® injections decrease your ability to contract the glabellar muscles re-creating a smooth and youthful forehead.

2. Crow’s feet (would like a lateral view of Crow’s feet)

These lines are also called lateral canthal lines or periorbital lines. They branch out from the outer corners of the eyes while squinting or smiling.

Crow’s feet appear because of the loss of collagen and skin elasticity and extensive sun exposure.

When we repeatedly make facial expressions like squinting, the muscle around the eye contracts and causes the skin to fold, eventually causing crow’s feet to appear. Sadly, these wrinkles can occur at a really young age like mid-20s. The skin around the eyes is quite thin and loses elasticity with age and wear. It has limited capacity to bounce back to its relaxed state as it used to.

Fortunately, BOTOX® is a fast and effective treatment to reduce the muscle activity underneath the skin and improve these wrinkles. It reduces the visibility of crow’s feet by relaxing the muscles that surround the eyes. After obicularis oculi (eye muscle) BOTOX®, you should notice that the skin underneath and around your eyes looks smoother, and the difference should be particularly distinctive when you smile.

3. Forehead Wrinkles

Forehead wrinkles are caused due to many factors like losing skin elasticity and using the forehead muscles to open your eyes and raise your eyebrows. Repeated use of the frontalis muscle causes wrinkles across the forehead.

So, as the skin matures it loses its laxity. Combined with gravity and facial muscle contractions forehead wrinkles and fine lines are formed.

BOTOX® is actually one of the most effective ways in reducing forehead wrinkles. It smooths the horizontal lines and vertical wrinkles between the eyes. The injections work to relax the muscles that cause these wrinkles to form. It prevents the muscles from contracting and thus the creases get softened. After the treatment, the forehead is much smoother as the wrinkles don’t appear anymore.

4. Bunny Lines

These wrinkles appear on the bridge of your nose especially when you scrunch up your nose when laughing. When you overuse facial muscles called nasalis muscles they show up straight or a bit diagonally on both sides of your nose under the bridge. As you get older, they stay around appearing as fine lines, even if your face is relaxed.

They might have a cute name but they are still a type of wrinkles that you worry about. Botox injections temporarily limit the movement of your facial muscles. It is an effective way to minimize the appearance of bunny lines.

5. Lipstick Lines

Lipstick or smokers’ lines are wrinkles that appear on the lower and upper lip and fan out from the lip border. They are also known as pucker lines or perioral rhytids.

These wrinkles get even more prominent when you pucker your mouth by using Orbicularis Oris muscle that borders the mouth. These lines also appear because of the loss of collagen that happens as the skin ages and the constant clustering of the tissue because of muscle contractions. They make the lipstick run and smudge outside the lips - that’s how they got their name.

BOTOX® is a very common treatment for lipstick lines no matter how deep the lines are. It is effective because it relaxes the lines and eventually smooths them. Both upper and lower lip lines can be effectively treated. Botox is a simple in-office procedure and takes about 10 minutes. It causes minimal pain and downtime.

BOTOX® is injected in Orbicularis Oris muscle which results in temporarily freezing its movements. But you are of course still able to move your mouth as you normally do.

That’s one of the advantages of BOTOX® - it gives an absolutely natural appearance to the treated area.